| When talking with a naturopath he told us to take, first thing in the morning before anything else, one ounce of vegetable oil and follow with four ounces of grapefruit juice... we substituted four ounces of water with a teaspoon of vinegar. We were never bothered again with any pains... a year later we ran out of oil and did not use any for three weeks. The gall bladder pains returned, but immediately left as soon as we started the oil and vinegar water again. Now another year has gone and we are still not bothered with gall bladder pains."
* R.K. |
John Heinerman
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 He persuaded the astonished wife to pick the tender young alfalfa shoots, chop them up very fine and combine them with equal parts of water and canned grapefruit juice.
The patient was also given canned vegetables, whole grain bread and raw milk in the correct amounts. Eventually, the leg condition completely healed up with the farmer strictly adhering to this dietary regimen. |
Marion Nestle
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 Advertising promotes the sales of specific food products and in proportion to the amount spent, as shown for commodities such as milk, cheese, grapefruit juice, and orange juice. Food sales increase with the intensity, repetition, and visibility of the advertising message.24 Promotion of nutritional advantages (low-fat, no cholesterol, high-fiber, calcium-added) increases sales, as does the use of health claims (lowers cholesterol, prevents cancer). Cigarette company-owned food advertisers are particularly adept at using charity to sell food products, as shown in Figure 5. |
Ruth Winter
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 If you must eat nitrite-laced meats, include a food or drink high in Vitamin C at the same time—for example, orange juice, grapefruit juice, cranberry juice or lettuce.
NITRO • A prefix denoting one atom of nitrogen and two of oxygen. Nitro also denotes a class of clyes derived from coal tars. Nitro dyes can be absorbed through the skin. When absorbed or ingested they can cause a lack of oxygen in the blood. Chronic exposure may cause liver damage. See FD and C Colors. |
Joe Graedon and Teresa Graedon
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 Trough Concentrations of Cyclosporine in
Blood Following Administration with grapefruit juice." Br. J. Clin. Pharmacol. 1993; 36:457-459.
11. Fairweather-Tait, S., et al. "Orange Juice Enhances Aluminium Absorption from Antacid Preparation." European J. Clin.Nutr. 1994; 46:71-73.
12. Tarnawski, Andrzej, et al. "Cytoprotective Drugs: Focus on Essential Fatty Acids and Sucralfate." Scand. J. Gastroenterol. 1987; 22(Suppl. 127):39-43.
13. Mezenova, T.D. "Hypolipidemic Activity of Licorice Root Extract."
Pharm. Chem. J..(USSR) 1984; 17:275-277.
14. Shinada, Masahiro, et al. |
Stephen Fried
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 Cheerios and a glass of grapefruit juice.
After the next break, Oprah spoke with a woman who had suffered a stroke while taking birth control pills. The woman described waking up one morning and feeling an arm on her chest: she assumed it was her husband's draped over her, but when she lifted it, she realized it was her own. The entire left side of her body had been paralyzed, and several years later she was still walking with a cane. She and her husband had sued the drug company, but she had been found partially responsible for her fate. |
Robert Hass, M.S.
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 When the greens begin to wilt and the volume starts to reduce, add the grapefruit juice. Let the juice come to a boil. Add both the mustards and the Tabasco. Stir to blend. Reduce heat and cover the skillet loosely. Simmer to desired tenderness (usually 1-2 minutes), stirring occasionally.
Calorie Breakdown per Serving
Protein: 13.9% Carbohydrate: 51.7% Fat: 34.4%
Nutrition Totals per Serving calories: 48 protein: 1.8 grams carbohydrate: 6.5 grams fat: 1.9 grams sodium: 134 milligrams cholesterol 0 milligrams
-? |
| A single glass of grapefruit juice contains enough naringenin to increase the half-life (the time a drug or nutrient stays active in the body) of the cardiac drug nifedipine.
• Vitamin C: This powerful water-soluble antioxidant helps regenerate vitamin E, prevent LDL (low-density lipoprotein)-cholesterol oxidation, detoxify environmental carcinogens, and assist in the body's synthesis of hormones and connective tissue, bone, and cartilage. It is required to convert folic acid into its active form in the body, and it increases the body's ability to absorb and store iron. |
Stephen Fried
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| At the same time, he and others at Georgetown were quietly experimenting with using the grapefruit juice effect to lower the required dose of extremely expensive drugs. The brother of one of the department's pharmacologists was taking the very pricey antirejection drug Sandimmune (cyclosporine), and they were wondering if he could halve the dose with the right amount of Tropicana.
Graedon then moved on to the problems caused by drugs interacting with other drugs. His concern was not only adverse reactions but unpleasantly surprising drug inactions. |
John Heinerman
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 These firms pack canned grapefruit sections and fresh or frozen concentrated grapefruit juice. The Duncans have been replaced by a seedless variety called the marsh seedless. This variety originated from a chance seedling of the Duncan variety that produced seedless
97 grapefruit. The marsh seedless is a yellow-fleshed, seedless grapefruit that has fine flavor and texture and is fairly juicy, but it isn't quite as juicy as the Duncan. All the golden-fleshed grapefruit sold to consumers for table use are of the marsh seedless variety. |
H.J. Roberts, M.D.
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 These data indicate the following:
• Orange juice and grapefruit juice average as much as ten times more ethanol, and from two to ten times more acetylaldehyde, than methanol.
• The concentration of methanol is higher in fresh-squeezed orange juice compared to the small amounts in pasteurized orange juice (22mg/liter), frozen concentrate (3.4mg/liter), reconstituted juice from concentrate (trace/one glass), and orange juice in tin cans (trace). |
James A. Duke, Ph.D.
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 In another Harvard study involving 45,000 male health professionals, both apple juice and grapefruit juice appeared to increase kidney stone risk. If you've already had a stone, I'd advise avoiding these beverages, as much as I love them.
Garnish your beverage with a slice of lemon. Lemon juice contains citric acid, which helps prevent the formation of calcium oxalate crystals in urine. Other good sources of citric acid include lime, pomegranate, tangerine, strawberry, purslane, potatoes, soy, and roselle, a major ingredient in Red Zinger herbal tea. |
Ben Davis
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| If you are troubled with nervous conditions, beat a raw egg until fluffy and add to a glass of freshly squeezed grapefruit juice.
3The Natural Way to Health Through Controlled Fasting, by Carlson Wade (Parker Publishing Company, Inc., West Nyack, N.Y.), 1968.
DINNER.............. This may be similar to your breakfast. You can vary the whole wheat dish by taking oat porridge—or put raw, soaked oats through a blender and eat with a spoon.
This one-day cleansing diet menu permits you to eat, but is carefully composed of easily digested foods that leave little waste residue. |
Simon Mills and Kerry Bone
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 Inactivation of cytochrome P450 3A4 by bergamottin, a component of grapefruit juice. Chemical Research in Toxicology 1998; 11 (4): 252-259.
316. Woo WS, Shin KH, Lee CK. Effect of naturally occurring coumarins on the activity of drug metabolizing enzymes. Biochemical Pharmacology 1983; 32 (11): 1800-1803.
317. Steinegger E, Hovel H. Analytic and biologic studies on Salicaceae substances, especially on salicin. II. Biological study. Pharmaceutica Acta Helvetiae 1972; 47: 222-234.
318. Fotsch G, Pfeifer S, Bartoszek M et al. Biotransformation of phenolglycosides leiocarposide and salicin. |
| Some foods can be used to inhibit gut biotransformation, e.g. grapefruit juice.
• The frequency of dosage should be based on bioavailability and metabolism.
15. Langenheim HJ. Higher plant terpenoids: a phytocentric overview of their ecological roles. Journal of Chemical Ecologv 1994; 20 (6): 1223-1280.
16. Callaway R. Positive interactions among plants. Botanical Review 1995; 61 (4): 306-349.
17. Patroni C. Aspirin as an antiplatelet drug. New England Journal of Medicine 1994; 330 (18): 1287-1294.
18. Wu C, Hsieh M, Huang S et al. |
| In a crossover study with a healthy volunteer, grapefruit juice given at the high dose of 1 litre with coumarin (10 mg) retarded the appearance of umbelliferone.33
CLINICAL TRIALS WITH COUMARIN
Most clinical trials were conducted using oral doses of a combination of coumarin and troxerutin. These trials have shown beneficial effects in haemorrhoids,34 acute pancreatitis35 and the complications of varicose veins, particularly varicose ulcers, oedema and subjective symptoms. |
the Editors of PREVENTION
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 Burdock, Oregon Grape,
Yellow Dock, and Siberian Ginseng
Take 1 teaspoon of blended tincture twice a day in grapefruit juice. Like many naturopathic doctors, Thomas Kruzel, N.D., former president of the American Association of Naturopathic Physicians, who practices in Portland, Oregon, draws a link between psoriasis and a deficiency in the body's ability to rid itself of toxic substances.
Cause: The cause of psoriasis is still a mystery, but doctors think heredity may be involved. |
Simon Mills and Kerry Bone
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| In addition, they may be responsible for the enhanced bioavailability which grapefruit juice affords to several pharmaceuticals (see Pharmacokinetics section, p.58).
The decoction of the fruits oiAmmi visnaga has been used since ancient times in Egypt as a spasmolytic for kidney stones and in the treatment of angina pectoris. The pyranocoumarin visnadin was isolated which exhibited positive inotropic and marked coronary vasodilatory activities. Visnadin is still used as a treatment for angina and possibly acts as a calcium channel blocker. |
Elizabeth Somer, M.A., R.D.
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 Serve with fat-free crackers and grapefruit juice.
• Cooked large white beans (fava) marinated in lemon juice, garlic, fresh sage, and wine. Serve with French bread.
• One soft pretzel, served with 6 ounces low-fat strawberry-kiwi yogurt with one peeled and chopped kiwi fruit.
• One slice cheese pizza, piled high with grilled vegetables, such as green or red bell pepper red onions, mushrooms, eggplant, and zucchini. Serve with fruit juice.
• Three fig bars and I cup warmed nonfat milk flavored with almond extract and sprinkled with nutmeg. |
Stephen Fried
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| As a precaution, never take any medication with grapefruit juice. It can inhibit many drugs from being normally metabolized through the liver, which can cause a standard dose to become an overdose.
5. Follow dosing instructions. If the drug is labeled to be taken on an empty stomach, or with food, or with plenty of fluids, then do what the label says. If you are unclear how long your stomach has to be empty, or how much food or fluid is necessary, don't be afraid to ask. If you just guess, you could guess wrong. |
Elizabeth Somer, M.A., R.D.
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| Serve with grapefruit juice.
13. Prepare hot cereal the night before: Place dry cereal (quick-cooking oats, Wheatena, multigrain cereals, etc.) in a preheated, wide-mouth thermos. Add steaming milk and close tightly. The cereal will be ready and warm by morning. Serve with fresh fruit and orange juice.
14. Breakfast sandwich: Toast whole wheat, pumpernickel, or rye bread and top with a slice of Muenster or farmer cheese mixed with dried fruit. Serve with fresh fruit or juice,
15. |
| Include two servings of fruits (or vegetables) from the following list:
• 6 ounces 100 percent fruit or vegetable juice (avoid all juices made with "pure grape" or "pure apple juice concentrate," since these "all-natural" fruit beverages are actually primarily sugar water Instead, choose 100 percent orange juice, grapefruit juice, orange-pineapple juice, tomato juice, or fresh squeeze your own juices if you have time. |
John Heinerman
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| I instructed her to gather the tender little alfalfa shoots, mince them very fine and mix them with water and grapefruit juice, which was available at a grocery many miles away." Besides this, the ailing fellow also was told to consume canned vegetables, whole wheat bread and raw cow's milk in the right proportions. "In time," Bieler concluded, "the ulcer healed entirely and the swelling disappeared. Needless to say, he never resumed his diet of hog fat, white flour and white sugar. |
Simon Mills and Kerry Bone
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| For example, it increases the bioavailability of oral 17-beta-oestradiol and its metabolite oestrone.305 grapefruit juice also substantially increases the bioavailability of the following drugs: felopidine,306 caffeine,307 nifedipine and similar drugs,308 cyclosporine309 and triazolam310 and similar drugs. The major interaction seems to be in the gut wall with enzymes belonging to various cytochrome P-450 subfamilies.311 It also appears to inhibit renal 11-beta-hydroxysteroid dehydrogenase in humans and could therefore potentiate side effects from licorice. |
John Heinerman
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| Yield: 1 cup
Blackberry Sour
1/4 cup grapefruit juice */2 cup mineral water, chilled 1 tablespoon lemon juice */2 cup blackberries 1 cup ice cubes
Blueberry Fig and Date Shake
2 cups goat milk (or skim) 2 tablespoons lemon juice 1 tablespoon pure maple syrup */2 teaspoon ground cinnamon */2 cup pitted dates */4 cup figs
1 cup frozen blueberries
Place all ingredients in a blender container in the order listed. Secure lid. Blend on HIGH speed until smooth. Serve immediately. |
Janet Zand, LAc, OMD, Allan N. Spreed, MD, CNC, James B. LaValle, RPh, ND
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 Anyone taking any of these drugs should avoid grapefruit juice altogether.
A well-known type of food-drug interaction occurs with a class of drugs known as monoamine oxidase (MAO) inhibitors, commonly prescribed for depression.
Examples include isocarboxazid (Marplan), phenelzine (Nardil), and tranylcypromine (Parnate). People who take these drugs can suffer potentially serious consequences—including headaches and sharp, sudden rises in blood pressure—if they consume foods that contain a substance called tyramine. |
Ben Davis
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| When talking with a naturopath he told us to take, first thing in the morning before anything else, 1 ounce of vegetable oil and follow with 4 ounces of grapefruit juice...we substituted 4 ounces of water with a teaspoon of vinegar. We were never bothered again with any pains.. .a year later we ran out of oil and did not use any for three weeks. The gall bladder pains returned, but immediately left as soon as we started the oil and vinegar water again. Now another year has gone and we are still not bothered with gall bladder pains."
Squash is extremely high in vitamin A (4,9501.U. |
| The first night of this fast 4 ounces of olive oil and 4 ounces of grapefruit juice were taken together just before retiring, in order to stimulate the action of the liver and gall bladder. This fast was taken for 14 days. No attack occurred during this period, and the following diet was taken at the end of the 14 days:
Breakfast—2 coddled eggs.
2 pieces hard, dry, brown toast.
1 dish cooked apple sauce without sugar.
Lunch— 2 raw apples with 1 ounce of either pecan or almond nuts, together with a glass of water.
Dinner— 1 small piece of broiled steak. 1 dish of spinach. Raw celery. |
David Heber, M.D., Ph.D.
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 This type of interaction of chemicals in grapefruit juice with your genes is an example of how diet can powerfully affect the body's enzyme systems. There are many other examples mentioned later, but the point is that these enzyme changes also can protect your body from chemicals in the diet or the environment.
DNA Damage and Common Diseases
As we age, our DNA protection systems become less effective and we generate more oxygen in our cells. Damage to our DNA piles up, and some of the changes in our genes lead to heart disease, cancer, and Alzheimer's disease. |
Stephen Fried
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| In the interim, the FDA would put new label warnings on Seldane— including one that finally urged patients not to take the drug with grapefruit juice, as Dave Flockhart had first discovered. {The Oprah Winfrey Show ended up scooping the FDA on this warning by approximately four years.) Lost in this whole scramble was the fact that Seldane and Allegra were not identical, only similar. When the 1997 allergy season began, a guy I play basketball with would lament the virtual unavailability of Seldane, which he had used successfully, without side effects, for years. |
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