Sheldon Saul Hendler and David Rorvik
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 Naringe-nin and/or other substances found in grapefruit juice inhibit cytochrome P-450 3A4 (CYP 3A4). Drugs affected include the calcium channel blocker felodipine, as well as carbamazepine, cyclosporine, lovastatin, simvastatin, saquinavir and nisoldipine. Those taking these drugs need to exercise some caution in the use of any grapefruit products.
NUTRITIONAL SUPPLEMENTS
Copper: One study showed that high doses of vitamin C negatively affected copper status in men. Other studies have not shown such effects.
Flavonoids: Vitamin C may act synergistically with various flavonoids. |
| Therefore, concomitant use of red yeast rice and grapefruit juice may increase the risk of myopathy.
Meals: When lovastatin was given under fasting conditions, plasma concentrations of lovastatin and its active metabolite were on the average two-thirds those found when lovastatin was administered immediately following a meal.
OVERDOSAGE
There are no reports of overdosage with red yeast rice. A few cases of accidental overdosage have been reported with the pharmaceutical form of lovastatin. The maximum dose taken was 5-6 grams. |
Mark Stengler, N.D.
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 Some people have to be wary of grapefruit and grapefruit juice, however, because it affects the way the liver metabolizes certain drug medications. The fruit and concentrated juice have been shown to alter the blood levels of some heart medications and antidepressants, sometimes causing the drugs to have a greater than anticipated effect.
PHYTONUTRIENTS
Recommendations from the Natural Physician for .
Some phytonutrients seem very effective in boosting general good health, while others are ones I'd rec-ommend for specific conditions. |
John Heinerman
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 She mixed equal parts of this manzanita cider with orange or grapefruit juice, added one tablespoon of apple cider vinegar, and gave it to those who came to her with allergy problems.
VALERIAN
(Valeriana officinalis)
Brief Description
Common valerian is a perennial plant, about 2-4 feet high, which has escaped from cultivation to inhabit roadsides and thickets from New England south to New Jersey and west to Ohio. It is also very common all over Europe. |
Isadore Rosenfeld, M.D.
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 Although three or four glasses of orange or grapefruit juice at one sitting may give you an upset stomach, citric acid has no effect on an ulcer one way or another. The cardinal rule for people with peptic ulcers is to avoid any food or liquid that they know from previous experience causes them distress.
The incidence of peptic ulcers has decreased significantly in the past few years and one of the reasons may be the increasing substitution of saturated fats by vegetable oils. Vegetable oils contain linoleic acid, a precursor of prostaglandin, which protects the lining of the intestinal tract. |
| Since the average American diet contains about 60 to 65 meq a day, you do not really need to increase your potassium intake by more than 10 meq a day—or an extra glass of grapefruit juice. That should reduce your risk of stroke by 40 percent regardless of its effect on your blood pressure. Blacks (50»percent of whom over age sixty-five have high blood pressure) who live in the southeastern United States and consume an average of only 30 meq of potassium, less than half the average consumed by the rest of the country, have the highest stroke incidence in the nation. |
Barnet Meltzer, M.D.
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 When you want to lose weight, down a glass of fresh squeezed grapefruit juice. Like oranges, grapefruits are a great way to start the day. Fit one into your Sunrise Cleanse, after your morning workout and right before you meditate.
Therapeutic and Healing Powers: I consider grapefruits to be the leading circulatory antiseptic. In other words, these power citruses are potent blood cleansers, which is precisely why they're so valuable in the prevention and treatment of bacterial and viral infections. |
Joe Graedon and Teresa Graedon
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 Do not take Sandimmune with grapefruit juice unless the physician is monitoring blood levels of the drug closely. (See page 43.) Due to a possible interaction between cyclosporine and oral contraceptives, barrier methods of contraception should be used while taking this drug.
Regular monitoring is important. Do not stop this medicine unless your doctor so directs.
INTERACTION
Carbamazepine can increase the speed with which the body disposes of Sandimmune. In some cases, blood levels of Sandimmune drop below detectable limits after carbamazepine is added. |
The Complete Book of Alternative NutritionSelene Y. Craig, Jennifer Haigh, Sari Harrar and the Editors of PREVENTION Magazine Health Books
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| Fill your fridge with cooling foods like watermelon, seaweeds, grapefruit juice, cucumbers, whole-wheat pitas and other breads.
You can help yourself to lots of salads, stir-fries, beans and rice dishes. But you might need to make some strategic substitutions, using sweet peas instead of hot peppers and cucumbers instead of onions.
Preparing dinner can be a lengthy chore if you follow Chinese nutrition recommendations and use dried beans instead of canned. |
Robert Hass, M.S.
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 Vitamin C-rich foods includes oranges, orange juice, papaya, grapefruit and grapefruit juice, strawberries, green bell pepper, broccoli, Brussels sprouts, cantaloupe, cabbage, and mustard greens.
VITAMIN D
Sunlight stimulates a hormone in skin that triggers the liver and kidney to make the active form of vitamin D3. Two equally effective sources of vitamin D in humans are derived from plant ergosterol, which is converted to ergocalciferol (vitamin D2) and cholecalciferol (vitamin D3) by the action of sunlight on the skin. |
Francois Couplan, Ph.D.
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 Fresh grapefruit juice is an excellent drink. It is also commercially canned. Grapefruits contain vitamins A, B, C and niacin, minerals, citric acid, an essential oil and various substances.
They are tonic, stomachic, depurative and refrigerant.
C. reticulata (= C. nobilis), mandarin The cultivar 'Deliciosa' is known as "tangerine." The small fruit, sweet and aromatic, is eaten raw. It is slightly sedative.
Many other species are used for their edible fruits in East Asia.
Poncirus trifoliata (D 5) Trifoliate Orange From the old French "poncire," a kind of citron. |
Judith Wills
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 M Top ten quick and healthy breakfasts
1 % cup (150 g) low-fat yogurt with 1 small banana chopped in, Vi grapefruit or glass of grapefruit juice, large slice of whole-wheat bread with a little olive oil margarine and honey.
2 % cup (150 g) low-fat yogurt topped with 2 oz (50 g) no-added-sugar luxury muesli and a portion of strawberries, small slice of bread with olive oil margarine.
3 Multigrain cereal with 2 teaspoons of chopped walnuts and skim milk to cover, handful of dried ready-to-eat apricots, 1 slice of bread, olive oil margarine and honey, glass of orange juice. |
Joe Graedon and Teresa Graedon
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| Taking Plendil with grapefruit juice may lead to unexpectedly high blood levels. See the table of Food and Drug Interactions on pages 59-73 for specifics. If the drug must be discontinued, follow your doctor's instructions for gradual tapering.
Never take or stop medication without your doctor's advice.
INTERACTION DANGEROUS
Anticonvulsant Lithium
(CARBAMAZEPINE) *
BRAND NAME GENERIC NAME
Tegretol carbamazepine DESCRIPTION
Carbamazepine is often prescribed to people for whom other anticonvulsants have not worked well. |
Alan Keith Tillotson, Ph.D., A.H.G., D.Ay.
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 Drinking grapefruit juice when taking cardiac glycosides could raise our blood levels and be dangerous.
Individual variations in our cytochrome P40 enzymes help to demystify why there are so many variations in how we respond to drugs and herbs. This is why one man's herbal meat is another man's herbal poison. A well-trained medical practitioner can exploit these facts to your advantage. For more information on this process with common drugs, and a few herbs, look for Dave Flockhart's Drug Table on the web at http://www.dml.georgetown.edu/ depts/pharmacology/davetab.html. |
| If you are not taking such medicines you certainly can drink grapefruit juice.
Blood Thinners
Many herbs contain mild to moderate blood-thinning or -thickening properties. For example, foods and herbs containing vitamin K (which allows the body to produce proteins that clot blood) are widely distributed in nature. Because the actions by themselves are not strong, and because there are many steps in the pathway of coagulation, they almost never pose a danger. |
Larry Trivieri, Jr.
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 Loomis also prescribes a detoxifying cocktail that combines garlic, lemon juice, grapefruit juice, and olive oil. This is given at bedtime because the liver, a major organ for detoxification, is most active between 11 p.m. and 1 a.m., according to traditional Chinese medicine.
In addition, juice therapy offers a balanced way to supplement the diet, according to Steven Bailey, N.D., of the Northwest Naturopathic Clinic, in Portland, Oregon. "One of the most convenient therapies available is the use of raw fruit and vegetable juices to augment the typical diet. |
Joe Graedon and Teresa Graedon
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| Do not take Sandimmune with grapefruit juice unless the physician is monitoring blood levels of the drug closely. (See page 43.)
Due to a possible interaction between cyclosporine and oral contraceptives, barrier methods of contraception should be used while taking this drug.
Regular monitoring is important. Do not stop this medicine unless your doctor so directs.
INTERACTION
Dilantin, and presumably the other drugs in its class, seems to interfere significantly with the absorption of Sandimmune. |
Larry Trivieri, Jr.
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| Or mix Vs ounce each of grapefruit juice and olive oil and take prior to meals.
NUTRITIONAL THERAPY: • Multi-enzymes with bile (bile is contraindicated if ulcers coexist) • Vitamin C • Vitamin B complex • Choline and inositol • Lipotropic factors • Alfalfa tablets • Lecithin • Unsaturated fatty acids • Acidophilus • L-taurine • Peppermint oil sipped in water throughout the meal may be helpful when having symptoms.
Self-Care
77r following therapies can be undertaken at home under appropriate professional supervision.
Fasting / Yoga
HERBS: In conjunction with dietary and lifestyle advice. |
Joe Graedon and Teresa Graedon
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| Do not take Sandimmune with grapefruit juice unless the physician is monitoring blood levels of the drug closely. (See page 43.) Due to a possible interaction between cyclosporine and oral contraceptives, barrier methods of contraception should be used while taking this drug.
Regular monitoring is important. Do not stop this medicine unless your doctor so directs.
INTERACTION
A transplant patient who comes down with an infection needs an antibiotic, and co-trimoxazole may be appropriate. This should be undertaken only with very careful follow-up and monitoring. |
Robert Hass, M.S.
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| Rats fed a high-fat diet developed more tumors than rats fed a low-fat diet, but tumor development was delayed in the groups given orange or grapefruit juice. Rats given orange juice had fewer total tumors than did control subjects. Orange and grapefruits are effective inhibitors of human breast-cancer cell proliferation, especially in the presence of quercetin, which is widely distributed in many other foods. Have one to two servings of citrus fruits each day.
TABLE 5. |
Joe Graedon and Teresa Graedon
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| You have learned that such simple pleasures as licorice, grapefruit juice, chicken nuggets, and vanilla pudding can have unexpected and undesirable consequences when taken with certain drugs.
You would think that physicians have ready access to basic dosing instructions. After all, how you take your pills can have a profound effect on how well they get into your bloodstream and work in your body. Despite the importance of this essential information, it's not readily available. Only a few entries in the Physicians' Desk Reference specify how a pill should be swallowed in relation to meals. |
Elizabeth Somer, M.A., R.D.
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 Serve with one slice whole wheat bread, toasted, topped with I tablespoon apricot preserves, and 6 ounces grapefruit juice.
BREAKFAST #8
Breakfast burrito: Saute chopped onion, garlic, and green pepper in I tablespoon water until tender. Add Ui cup egg substitute, salt and pepper to taste, and scramble. Heat a 10-inch flour tortilla and fill with egg mixture, lh ounce grated sharp cheddar cheese, and I tablespoon fresh salsa. Serve with I cup fresh orange juice and a decaffeinated latte made with skim milk. |
Carlton Fredericks, Ph.D.
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| V* cup 4
Fruits and fruit juices:
Fruit cocktail 120
Orange juice 100
Pineapple juice, 100 unsweetened grapefruit juice, 100 unsweetened Grape juice, 100 commercial gm. Vfe cup, scant I gm. V2 cup, scant 2 gm. % cup, scant 23/: gm. Y2 cup, scant 21/; gm. % cup, scant 3%
Now that we have coped with the arguments of those who believe they use no sugar or very little, let's take care of the woman who frankly confesses a sweet tooth. If her craving for sugar is really compulsive, she is more deserving of sympathy than you might suppose, because she may be a victim of an unrecognized allergy. |
Sheldon P. Blau, M.D., F.A.C.P., F.A.C.R. and Elaine Fantle Shimberg
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 To be safe, wait at least four hours after taking medicine to drink grapefruit juice.
Even a sweet treat like licorice, brought to you by a well-meaning visitor, can be dangerous and potentially fatal, as copious amounts of licorice can draw potassium from your system and dangerously interact with medications such as Lanoxin, which is used for congestive heart failure and disturbances of the heart rhythm. Before you ingest any food (including seemingly harmless treats such as candy or gum), check with your physician. |
Gary Null
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 Instead, you should have apple juice, prune juice, or grapefruit juice.
Then, enjoy a steaming bowl of wheatena or cream of wheat. These cereals are available everywhere. They are loaded with nutrition and high in fiber. But, to get more fiber into your system, to help cleanse your system, eat a bran muffin as well and be sure it's unsweetened. snack: For a midmorning snack, have another bran muffin, since it contains only 70 calories. The muffin will help fill you up, but will also pass easily through your system. lunch: For lunch, start off with some navy bean soup. |
Robert S. McCaleb, Evelyn Leigh, and Krista Morien
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 The effect is strong enough that sensitive people can overdose on the prescription drugs if they are frequently taken in combination with grapefruit juice. Since that discovery, researchers have learned that substances in broccoli, cauliflower, wheat, corn, coffee, tea, and tobacco also affect this liver enzyme system. There are certainly many other discoveries to be made in this emerging science, and some of these may involve herbs or nutritional supplements. For now, there are some known interactions, and these are detailed for each herb in Part II. |
Dian Dincin Buchman, Ph.D.
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 Add some pith to your grapefruit juice.
Vitamin A vegetables are also anti-infection aids. One glass of freshly extracted carrot juice contains about 17,000 IU of vitamin A. Alternate the carrot juice with occasional drinks of juiced mixed green vegetables combined with carrot.
The ancient Egyptians taught us the value of figs as medicine. Boil 2 ounces of figs in 2 cups of boiling water. Cool, strain out the figs, and gargle with the water. The figs may be eaten separately and will help to overcome constipation. |
Jean Carper
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 So to get cholesterol-lowering benefit, you must eat the chewy stuff. grapefruit juice is not high in pectin and does not depress blood cholesterol.
HONEY
POSSIBLE THERAPEUTIC BENEFITS:
¦ Kills bacteria
¦ Disinfects wounds and sores
¦ Reduces perception of pain
¦ Alleviates asthma
¦ Soothes sore throats
¦ Calms the nerves, induces sleep
¦ Relieves diarrhea
FOLKLORE
Honey was to the ancient Egyptians what aspirin is to modern medicine: the most popular among drugs. |
Patricia Hausman & Judith Benn Hurley
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 In a small bowl, whisk together grapefruit juice, oil, and mustard. Pour over scallop mixture and toss well to combine. Serve at room temperature or chilled on lettuce leaves.
Variation: Add a bit of chopped avocado to the salad before tossing with dressing. |
Rex Adams
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 If your doctor has determined with X-rays that your gallstones are small enough to be passed without getting stuck, an old folk remedy for passing them—occasionally recommended by doctors—is to mix half a cup of olive oil with half a cup of lemon or grapefruit juice, stir, drink and go to bed. You may experience nausea. In the morning, drink something hot and you may pass the stones from your bowels.
Another method is to fast for two days, drinking apple juice at two-hour intervals, and use the preceding method on the second night. |
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