Laurie Deutsch Mozian, M.S., R.D. See book keywords and concepts | Seldane now comes with warning labels to avoid grapefruit and grapefruit juice due to its naringenin content.
Pectin (PEK-tin). Pectin is a soluble fiber found mostly in apples and citrus fruits. Soluble fibers have the ability to be fermented while in the colon. During the process of fermentation, they create butyrate, a fatty acid that has anticancer properties.
Perillyl alcohol (PER-il-il AL-kuh-hawl). Perillyl alcohol is a potent monoterpene phytochemical found in cherries and in caraway seeds. It has demonstrated preventive and therapeutic properties against cancer. | The Editors of Prevention Magazine Health Books See book keywords and concepts | Look for these staples, offered in most hospitals: yogurt, wholewheat bread, spinach, carrots, broccoli, orange or grapefruit juice, V-8 or vegetable juice, oatmeal, bran cereal, fruits, beans, skim milk, stewed prunes, baked potatoes, baked or broiled fish and chicken.
If you're concerned that a family member or friend who's in the hospital isn't eating, visit at mealtime to help, suggests Melanie Roberts Affikian, a nutrition consultant in private practice in Wakefield, Massachusetts. "If you can't do that, ask the nursing staff to make that sure they help," she says. | | If you're trying to quit via a nicotine replacement product such as nicotine gum or a nicotine patch, then steer clear of orange juice, grapefruit juice and other acidic beverages, says Thomas M. Cooper, D.D.S., professor of oral health sciences at the University of Kentucky in Lexington and co-author of The Cooper/Clayton Method to Stop Smoking. "By making your urine more acidic, you clear your body of nicotine faster, which is what you don't want if you're trying to minimize withdrawal with a nicotine replacement product," he explains. | Prevention Magazine See book keywords and concepts | Compared to the flesh, grapefruit juice is a concentrated source of naringin. You can make your own juice, but ready-made may be better since, during commercial processing, parts of the healthful peel go into the juice.
Buy it red. Red grapefruits contain more lycopene than the white varieties. Good choices include Ruby Red, Flame, and Star Ruby, says Bill Widmer, Ph.D., research scientist with the Florida Department of Citrus Research Center in Lake Alfred.
HONEY-niARJNATED G P\A P E F RJJ i T
Grate about 1 teaspoon of the rind from 1 grapefruit. | | Or simply substitute orange juice (which doesn't contain naringin) for grapefruit juice when taking medications.
"is a very important, very potent antioxidant and free radical scavenger," says Paul Lachance, Ph.D., professor of nutrition and chairman of the department of food science at Rutgers University in New Brunswick, New Jersey. "Our cancer and heart disease situations would be a lot worse if not for the lycopene in our foods."
Grapefruit is also an excellent source of limonoids, which, like vitamin C, have been shown to have anti-cancer properties. | | A 6-ounce glass of grapefruit juice, for example, contains over 100 milligrams of various limonoid compounds.
Grapefruit is rich in an additional compound, naringin, which doesn't appear to be present in other fruits. In laboratory studies, naringin has been shown to stop the growth of some kinds of breast cancer cells.
Finally, grapefruit is an excellent source of vitamin C. It's one of the few foods that can provide more than the entire Daily Value (DV) in one serving. A cup of grapefruit sections contains 88 milligrams of vitamin C, 146 percent of the DV. | Jean Carper See book keywords and concepts | Foods With Antiviral Activity
Apples, apple juice, barley, black currants, blueberries, chives, coffee, collards, cranberries, ginger, garlic, gooseberries, grapes, grapefruit juice, lemon juice, mushrooms (notably shiitake), orange juice, peaches, pineapple juice, plums, plum juice, raspberries, sage, seaweed, spearmint, strawberries, tea, wine (red). | J. Robert Hatherill See book keywords and concepts | Whole Foods
Dozens of studies have endowed spices (such as rosemary and sage), soybeans, grapefruit juice, licorice, cauliflower, brussels sprouts, broccoli, and citrus fruits and oils as superior cancer bashers. To remain healthy, rely on whole foods (since many chemopreventive agents are destroyed by heat or food-processing techniques) in conjunction with vitamin supplements.
Vitamins and Nutrients
Many vitamins and other nutrients are also chemopreventive: beta-carotene, minerals such as zinc and calcium, fish oils such as omega-3 fats, and nondigestible fibers. |
Textbook of Natural Medicine 2nd Edition Volume 1Michael T. Murray, ND See book keywords and concepts | | Eight ounces of grapefruit juice contains enough of the flavonoid naringenin to decrease cytochrome P450 activity by a remarkable 30%. The common inhibitors of phase I detoxification are listed in Table 50.6.
Curcumin, the compound that gives turmeric its yellow color, is interesting because it inhibits phase I while stimulating phase II. This effect can be very useful in preventing certain types of cancer. Curcumin has been found to inhibit carcinogens, such as benzopyrene (the carcinogen found in charcoal-broiled meat), from inducing cancer in several animal models. | Cheryle R. Hart, M.D. Mary Kay Grossman, R.D. See book keywords and concepts | Processing changes their structure, however, so apple or grapefruit juice and applesauce are still listed here and must be linked with protein. We will discuss this further in the section on glycemic response on page 72. | Leo Galland See book keywords and concepts | It is mildly blocked if the drugs are taken along with grapefruit juice.73
The interaction between Nizoral and Seldane can kill people. If a person taking Seldane also takes Nizoral, the blockade of CYP-3A produced by Nizoral will greatly elevate the level of Seldane in the body. High Seldane levels can cause irregularities of the heartbeat, which can be fatal. The Nizoral-Seldane interaction received considerable notoriety a few years ago because of these dramatic effects. |
Textbook of Natural Medicine 2nd Edition Volume 1Michael T. Murray, ND See book keywords and concepts | | Effect of grapefruit juice on blood cyclosporin concentration. Lancet 1995; 345: 955-956
26. Nagabhushan M, Bhide SV. Curcumin as an inhibitor of cancer. J Am Coll Nutr 1992; 11: 192-198
27. Polasa K, Raghuram TC, Krishna TP, Krishnaswamy K. Effect of turmeric on urinary mutagens in smokers. Mutagenesis 1992;
7: 107-109
28. Hagen TM, Wierzbicka GT, Bowman BB et al. Fate of dietary glutathione. Disposition in the gastrointestinal tract. Am J Physiol 1990; 259: G524-529
29. Ketterer B, Harris JM, Talaska G et al. | Phyllis A. Balch, CNC See book keywords and concepts | Avoid grapefruit juice, however, if you are taking a calcium channel blocker for high blood pressure or—although this is unlikely in cirrhosis—if your doctor has given you any kind of anticoagulant drug.) Red chili peppers also contain a similar compound.
LI Burdock root, dandelion, and red clover aid in cleansing the blood, reducing the stress on the liver.
LI Take 30 milligrams of zinc and 3,000 milligrams of vitamin C daily. Low zinc levels are associated with an increased risk of cirrhosis and with a reduced capacity for breaking down alcohol. | | Ll Drinking coffee, tea, and wine may lower the risk of kidney stones, while drinking grapefruit juice may increase it.
ž The measures used to treat kidney stones and to prevent recurrences depend on the nature of the stone, so it is important to take any stone you pass to your health-care provider for analysis. There is some evidence that vitamin C is sometimes converted to calcium oxalate, which can become concentrated in the urine. This is a condition known as ascorbate-induced hyperoxaluria. For some people, this may result in the formation of kidney stones. This is rare, however. | Leo Galland See book keywords and concepts | Even orange or grapefruit juice, which are acid when swallowed, tend to create alkalinity in the urinary tract.
Our old friends the Lactobacilli not only colonize the intestinal tract but grow well in the vagina and the urethra, where they prevent growth of pathogenic bacteria.101 The application of vaginal spermicides like nonoxynol-9, found in many contraceptive creams, may kill Lactobacilli and give pathogens more ready access to the urinary tract.102 Taking Lactobacilli by mouth or inserting Lactobacillus capsules into the vagina may restore genital tract symbiosis and prevent infection. | Stephen T., M.D. Sinatra See book keywords and concepts | Breakfast: One glass of cranberry juice
Lunch: One glass of carrot juice with either frozen wheat grass, green barley, or chlorella added; one cup of ginger tea
Dinner: One glass of grapefruit juice and two bowls of miso broth (recipe on page 217)
Bedtime: One cup of either chamomile, ginger, or echinacea tea
In addition to the above, drink eight glasses of water per day. You will find the majority of the products listed above at your local health food store. | Barnet Meltzer, M.D. See book keywords and concepts | If you're feeling ravenous, have a glass of fresh squeezed grapefruit juice mixed with one tablespoon of brewer's yeast and one tablespoon of spirulina or Revita?it will satisfy your hunger.
Nutrient Value: Grapefruits are rich in vitamins Bj and C, flavonoids, and folic acid, and their water-soluble fiber has cholesterol-lowering properties.
Selection and Care: To ensure juiciness, choose grapefruits by weight rather than by size. Pick firm, thin-skinned, ripe grapefruits; avoid spongy, soft, indented ones. |
Textbook of Natural Medicine 2nd Edition Volume 1Michael T. Murray, ND See book keywords and concepts | | Avoidance of grapefruit juice and flavonoid preparations containing naringin is recommended when taking any of these drugs.
REFERENCES
1. Hertog MG, Feskens EJ, Hollman PC et al. Dietary antioxidant flavonoids and risk of coronary heart disease, the Zutphen Elderly Study. Lancet 1993; 342: 1007-1011
2. Rice-Evans CA, Miller NJ, Paganga G. Structure-antioxidant relationships of flavonoids and phenolic acids. Free Radical Biol Med 1996; 20: 933-956
3. Havsteen B. Flavonoids, a class of natural products of high pharmacological potency. Biochem Pharmacol 1983; 32: 1141-1148
4. | Michael T. Murray, N.D., Joseph E. Pizzorno, N.D. See book keywords and concepts | Grapefruit juice decreases the rate of elimination of drugs from the blood.36 Grapefruit contains a flavonoid called naringenin that can decrease cytochrome P450 activity by a remarkable thirty percent.
INHIBITORS OF PHASE I DETOXIFICATION
Drugs
Benzodiazepines (e.g., Halcion, Centrax, Librium,
Valium, etc. | | Antihistamines (used to treat allergies) Cimetidine and other stomoch-acid-secretion-blocking drugs (used for stomach ulcers) Ketoconazole Sulfaphenazole
Foods
Naringenin from grapefruit juice Curcumin from the spice turmeric Capsaicin from red chili pepper Eugenol from clove oil Other Aging
Toxins from inappropriate bacteria in the intestines
Curcumin, the compound that gives turmeric its yellow color, is interesting because it inhibits Phase I while stimulating Phase II. This effect is also very useful in preventing cancer. | Isadore Rosenfeld, M.D. See book keywords and concepts | In a recent study conducted over a twelve-year period, no woman over fifty who consumed lots of potassium—more than 67 meq a day (there are 10 meq in one large glass of orange or grapefruit juice)—suffered a stroke. Those who took less than 40 meq had a stroke rate of 5.3 per 100. Similar results were observed in men. There were no stroke deaths among those who consumed more than 60 meq of potassium a day, but when the intake was less than 50 meq, there were 3.4 stroke deaths per 100 patients. | Barnet Meltzer, M.D. See book keywords and concepts | I recommend juices from fruits that are in season: Watermelon in summer, apple juice in fall, and orange or grapefruit juice from winter into spring. You don't have to strain half a watermelon every June morning, but do make sure the juice you buy is labeled "fresh-squeezed,'' not from concentrate. Drinking juice fifteen minutes before breakfast gives your digestive enzymes a gentle wake-up call while you're meditating. By the time you eat, your digestive juices will be at the ready for fruits and nuts.
4. | Ralph Golan, M.D. See book keywords and concepts | Grapefruit juice Very diluted fruit juices
Fresh fruit contains simple sugars that yeast feed on, although not as readily as the concentrated sweets. If your condition is not too serious, allow perhaps just one piece of fresh fruit daily (the less the better in the initial phase of treatment). Generally speaking, the less sweet fruit tastes, the less sugar is available for the yeast. So choose blueberries, for example, over strawberries, or grapefruit over oranges. Avoid snacking on dried fruit— raisins, dates, prunes, apricots, and the like—as these contain very concentrated sugars. | J. Robert Hatherill See book keywords and concepts | A variety of cancer-arresting fruit oils, called monoterpenes, are found in grapefruit, lemon, lime, sweet orange, bitter orange, and bergamot oils. grapefruit juice contains a flavonoid compound called naringin. Naringin has been demonstrated to protect from a mold toxin (anatoxin) that causes liver toxicity. A common citrus oil, limonene (the major component of lemon and orange peel oil), is also present in caraway, thyme, cardamom, and orange flower. Citrus liminoids are known to induce anticancer activities. | Elson M. Haas, M.D. See book keywords and concepts | Grape juice, grapefruit juice, and prune juice are also used, most often as breakfast drinks. The nectars of pears, peaches, or apricots may be special treats as well. Some juices are used therapeutically, such as papaya or pineapple for digestion or cranberry juice for soothing urinary tract irritations.
Children may drink a lot of fruit juice, more than adults, who are more given to coffee, tea, or alcoholic beverages, though soda pops have replaced some of the more natural fruit juices in young people as well. | Bill Gottlieb See book keywords and concepts | Besides bananas, some of the fruits highest in potassium include apricots, cantaloupe, dates, honeydew melons, kiwifruit, mangoes, nectarines, watermelon, avocados, grapefruit juice, oranges, papayas, pomegranates, prune juice, and raisins.
Some of the richest vegetable sources of potassium are Swiss chard, celery, spinach, parsley, watercress, endive, kohlrabi, broccoli, tomato juice, cucumbers, cauliflower, asparagus, artichokes, potatoes, sweet potatoes, and winter squash.
If you have kidney disease, high levels of potassium can be harmful. | Elson M. Haas, M.D. See book keywords and concepts | Potassium content is very good, and there is some calcium, magnesium, and phosphorus as well. grapefruit juice straight or mixed with orange juice is a high-vitamin C meal.
Lemons. Lemons have been a very useful food in my life. Lemonade fasting has done wonders for me and thousands of others who have attempted the "master cleanse" described in my book Staying Healthy with the Seasons (Celestial Arts, 1981). Lemon water, as a half lemon in a glass of water, drunk 20-30 minutes before meals, seems to help stimulate gastric juices and help digestion. | Earl L. Mindell, R.Ph., Ph.D. See book keywords and concepts | Antibiotics Anticonvulsants Azole antifungals is temporarily put on a macrolide antibiotic to treat chronic bronchitis, then has a glass of grapefruit juice and a cup of coffee with breakfast, raising his levels of the calcium channel blocker so high that his blood pressure drops precipitously, causing heart failure. It's not an unlikely scenario. Or let's say it's in the evening and he takes some Tagamet (which is available over the counter) for heartburn and a Valium to help him sleep. Our guess is that this type of mismatching kills hundreds of people every day. | | It's best in general not to take medicine with grapefruit juice unless your physician asks you to. Some calcium channel blockers may increase the amount of alcohol that gets into the blood when you have a drink or take medicine containing alcohol.
What Nutrients Do They Throw Out of Balance or Interact With?
Excess vitamin D may reduce the effectiveness of verapamil. Some calcium channel blockers, including nifedipine and verapamil, may bind with minerals in food or supplements, reducing the availability of the drug. | | And these are just the most commonly used drugs. grapefruit juice also uses this pathway, which is why drinking it is contraindicated with some drugs.
Are you getting the picture? This is a very popular pathway through the liver for clearing certain types of waste matter from the body. I'd like to see the FDA require a warning on the outside of every medication that is cleared through the P-450 pathways or that blocks P-450 pathways, so that every consumer is protected against unintentionally mixing these types of drugs. |
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