Earl L. Mindell, RPh, PhD with Virginia Hopkins, MA
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| How many people do you suppose have been killed in a scenario similar to this one: joe is taking a calcium channel blocker long term, is temporarily put on a macrolide antibiotic to treat chronic bronchitis, then has a glass of grapefruit juice and a cup of coffee with breakfast, raising his levels of the calcium channel blocker so high that his blood pressure drops precipitously, causing heart failure. It's not an unlikely scenario. |
| The following drugs can all interact dangerously with grapefruit juice: the calcium channel blockers (including felodipine, nicardipine, nifedipine, nimodipine, and isradipine), the statin drugs (lovastatin, simvastatin), the antianxiety drug buspirone, the benzodiazepine tranquilizers, the psychotropic drugs carbamazepine, nefazodone, and quetiapine, the antihistamine loratadine (Claritin), ethinyl estradiol (the main ingredient in oral contraceptives), the heart drug amio-darone, the impotence aid sildenafil (Viagra), and the steroid methylprednisone. |
Sheldon P. Blau, M.D., F.A.C.P., F.A.C.R. and Elaine Fantle Shimberg
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 There are ingredients called flavonoids in grapefruit juice that seem to intensify the levels of these and other drugs. In some cases, toxicity may result. To be safe, wait at least four hours after taking medicine to drink grapefruit juice.
Even a sweet treat like licorice, brought to you by a well-meaning visitor, can be dangerous and potentially fatal, as copious amounts of licorice can draw potassium from your system and dangerously interact with medications such as Lanoxin, which is used for congestive heart failure and disturbances of the heart rhythm. |
Robert S. McCaleb, Evelyn Leigh, and Krista Morien
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 For example, a few years ago it was discovered that grapefruit juice affects the liver enzyme system that metabolizes certain drugs. The effect is strong enough that sensitive people can overdose on the prescription drugs if they are frequently taken in combination with grapefruit juice. Since that discovery, researchers have learned that substances in broccoli, cauliflower, wheat, corn, coffee, tea, and tobacco also affect this liver enzyme system. There are certainly many other discoveries to be made in this emerging science, and some of these may involve herbs or nutritional supplements. |
Earl Mindell and Hester Mundis
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 GRAPEFRUIT JUICE
A great source of vitamin C, vitamins, and fiber, grapefruits also contain lycopene, an antioxidant that protects against heart disease and cancer. But grapefruit juice utilizes the same liver "pathway" as some drugs—which, if taken at the same time, may increase or decrease the effects of these drugs. (Blood pressure medications, antihistamines, cholesterol-lowering drugs, and some antidepressants are among the most commonly affected. Check with your pharmacist. |
Alan Keith Tillotson, Ph.D., A.H.G., D.Ay.
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 For example, drinking grapefruit juice will keep the expensive pharmaceutical drug Viagra in circulation longer, which means you could probably use half as much and save money. Drinking grapefruit juice when taking cardiac glycosides could raise our blood levels and be dangerous.
Individual variations in our cytochrome P40 enzymes help to demystify why there are so many variations in how we respond to drugs and herbs. This is why one man's herbal meat is another man's herbal poison. A well-trained medical practitioner can exploit these facts to your advantage. |
the Editors of FC&A Medical Publishing
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 But don't choose grapefruit juice. In a recent study, an 8-ounce serving of wine lowered the risk of kidney stones by 59 percent, while coffee and tea reduced risk by 8 to 10 percent. But grapefruit juice increased risk by 44 percent. r
Pantry pointers
Grapefruit isn't picked until it's ripe, so you don't have to worry about getting a "green" one. Choose one that feels heavy for its size, and you'll get a fruit that's juicy and tasty. You can store grapefruit at room temperature for a week or in the refrigerator for six to eight weeks. |
Phyllis A. Balch, CNC
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 LI Drink grapefruit juice, which contains a substance that can decrease the enzymatic conversion of many potential toxins to toxic forms by the liver by 30 percent. (Avoid grapefruit juice, however, if you are taking a calcium channel blocker for high blood pressure or—although this is unlikely in cirrhosis—if your doctor has given you any kind of anticoagulant drug.) Red chili peppers also contain a similar compound.
LI Burdock root, dandelion, and red clover aid in cleansing the blood, reducing the stress on the liver.
LI Take 30 milligrams of zinc and 3,000 milligrams of vitamin C daily. |
Michael T. Murray, N.D., Joseph E. Pizzorno, N.D.
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 For example, if you are taking drugs or are exposed to elevated levels of toxins, don't eat grapefruit or drink grapefruit juice. grapefruit juice decreases the rate of elimination of drugs from the blood.36 Grapefruit contains a flavonoid called naringenin that can decrease cytochrome P450 activity by a remarkable thirty percent.
INHIBITORS OF PHASE I DETOXIFICATION
Drugs
Benzodiazepines (e.g., Halcion, Centrax, Librium,
Valium, etc. |
Barnet Meltzer, M.D.
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 Anyone interested in permanent weight loss should be certain to have grapefruits and grapefruit juice as part of a daily diet. Both eliminate appetitis. If you're feeling ravenous, have a glass of fresh squeezed grapefruit juice mixed with one tablespoon of brewer's yeast and one tablespoon of spirulina or Revita?it will satisfy your hunger.
Nutrient Value: Grapefruits are rich in vitamins Bj and C, flavonoids, and folic acid, and their water-soluble fiber has cholesterol-lowering properties.
Selection and Care: To ensure juiciness, choose grapefruits by weight rather than by size. |
Joseph E. Mario
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 Lecithin, and fish.
•LIGHT Energy in rays of the sun, common energy throughout the universe works along certain patterns of action and reaction; is orderly and guided, intelligent, having a life force, vibratory rate, and electronic charge. Photons of sunlight carrying catalytic nutritional elements travel at 186,000 miles per second after 93 million miles from the sun composed of a range of electromagnetic vibrations from Gamma rays, through X-rays; Ultraviolet-A, -B and -C rays; to the Visible Rainbow spectrum of colors (designated 1 -100 on the Color Rendering Index/C.R.I. |
H. Winter Griffith, M.D.
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 Beverages:
grapefruit juice.
Risk of toxicity. Avoid.
Cocaine:
Increased adverse effects of carbamazepine. Avoid.
Foods:
None expected.
Marijuana:
Increased adverse effects of carbamazepine. Avoid.
Tobacco:
None expected.
BRAND NAMES
Sinemet Sinemet CP.
Stalevo
BASIC INFORMATION
Habit forming? No Prescription needed? Yes Available as generic? Yes Drug class: Antiparkinsonism
Controls Parkinson's disease symptoms such as rigidity, tremor and unsteady gait.
DOSAGE & USAGE INFORMATION
How to take:
• Tablet—Swallow with liquid or food to lessen stomach irritation. |
| Beverages:
grapefruit juice.
Decreased effect of itraconazole. Avoid.
Cocaine:
Decreased azole effect. Avoid.
Foods:
None expected.
Marijuana:
Decreased azole effect. Avoid.
Tobacco:
Decreased azole effect. Avoid.
GENERIC AND BRAND NAMES
See complete list of generic and brand names in the Generic and Brand Name Directory, page 872.
BASIC INFORMATION_
Habit forming? No Prescription needed? Yes, for some Available as generic? |
| Beverages:
grapefruit juice.
Increased effect of albendazole. Avoid.
Cocaine:
None expected.
Foods:
None expected.
Marijuana:
None expected.
Tobacco:
None expected.
BRAND NAMES
Anthra-Derm
Dritho-Scalp
Anthraforte
Lasan
Anthranol
Lasan HP
Anthrascalp
Lasan Pomade
Dithranol
Lasan Unguent
Drithocreme
Micanol
Drithocreme HP
BASIC INFORMATION
Habit forming? No Prescription needed? Yes Available as generic? No Drug class: Antipsoriatic, hair growth stimulant
• Treats quiescent or chronic psoriasis.
• Stimulates hair growth in some people (not an approved use by the FDA). |
| Beverages:
grapefruit juice.
Risk of toxicity with methylprednisolone or budesonide. Avoid.
Cocaine:
Unknown. Avoid.
Foods:
No proven problems.
Marijuana:
Decreased immunity.
Tobacco:
Increased adrenocorticoid effect.
GENERIC AND BRAND NAMES
See complete list of generic and brand names in the Generic and Brand Name Directory, page 868.
BASIC INFORMATION_
Habit forming? No
Prescription needed? For some
Available as generic? |
| Beverages:
grapefruit juice.
Risk of toxicity. Avoid.
Cocaine:
Decreased dextromethorphan effect. Avoid.
Foods:
None expected.
Marijuana:
None expected.
Tobacco:
None expected.
Others:
• If cough persists or if you cough blood or brown-yellow, thick mucus, call your doctor.
• Excessive use may lead to functional dependence. brand names
Choloxin basic information
Habit forming? No Prescription needed? Yes Available as generic? |
Phyllis A. Balch, CNC
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 Before Retiring
Drink a glass of grapefruit juice or Lemon Quality Water with 2 tablespoons of pure cold-processed olive oil added.
DAY 5
Your body should now be flushing toxins from all the major organs. Using only live foods and liquids accelerates the healing process. Be sure to drink plenty of liquids to help with elimination and speed healing.
Breakfast
Immediately upon rising, drink a glass of quality water to flush your kidneys.
Eat one serving of any kind of fresh fruit (except oranges). |
Eric R. Braverman
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 DINNER 6 oz. salad of beets and apples with 2 oz. goat cheese and balsamic vinegar (no olive oil). One grilled Cajun-spiced chicken breast and 4 oz. (total) of mixed steamed snow peas, red beans, and corn. Finish with ginger tea. your diet as much as possible, and reduce caffeinated beverages to no more than two cups per day. For some dopamine-related physical illnesses, you might want to eliminate foods high in saturated fat if you need to reduce your cholesterol, and carbohydrate restriction can help you lose weight and reduce fatigue.
DAY 3
BREAKFAST 2 oz. |
Phyllis A. Balch, CNC
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| Drink a glass of grapefruit juice or Lemon Quality Water with 2 tablespoons of pure cold-processed olive oil added. This aids in cleansing and healing the gallbladder. Repeat the oil and lemon juice drink just after rising in the morning and just before retiring at night for the next three days.
Drink a glass of unsweetened fruit juice with 1,000 milligrams of powdered vitamin C and your fiber supplement added.
Throughout the Day
Drink all the herbal tea, distilled water with lemon juice added, vegetable broth, and fresh juices as desired. |
Laurie Deutsch Mozian, M.S., R.D.
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 It is also an inhibitor of the cytochrome p450 enzyme system; however, this biological activity had a negative effect in a group of grapefruit juice drinkers who also were taking the allergy medication Seldane. The naringenin in the grapefruit juice bound with the cytochrome p450 in the blood, thus decreasing the amount of cytochrome p450 available to degrade the Seldane. Seldane remained in the blood longer than expected, and as people continued to take the drug, Seldane levels became dangerously high. |
Prevention Magazine
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 Thus far, drugs affected by grapefruit juice include calcium-channel blockers (used for high blood pressure), Seldane (an allergy medication), and Halcion (an anti-anxiety drug).
To avoid problems, be sure to read the package inserts that come with your medications. Or simply substitute orange juice (which doesn't contain naringin) for grapefruit juice when taking medications.
"is a very important, very potent antioxidant and free radical scavenger," says Paul Lachance, Ph.D. |
Robert Hass, M.S.
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 Pink Citrus Ice
YIELD: 4 SERVINGS
1 cup filtered water V2 cup sugar
1/2 cup Ocean Spray Ruby Red & Tangerine grapefruit juice Cocktail
V2 cup Tropicana Pure Premium Ruby Red Grapefruit Juice
For this dessert, use a durable pint container from a frozen dessert you may have purchased previously, but treat it carefully. Once you taste how good your own homemade fruit ice can be, you may never want to buy another one.
In a saucepan, heat the water and sugar to a boil. Stir the mixture constantly for 2 minutes, then remove the pan from the heat. |
Phyllis A. Balch, CNC
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| Drink a glass of grapefruit juice or Lemon Quality Water with 2 tablespoons of pure cold-processed olive oil added. This aids in cleansing and healing the gallbladder. Repeat this drink just after rising in the morning and just before retiring at night for the next three days.
Lunch
Eat a fresh raw vegetable salad (shred the vegetables if desired) topped with avocado, raisins, and sunflower seeds. Be sure to chew the food until it is almost liquid. You can now use an olive oil and balsamic vinegar dressing. (See the recipe on page 21. |
Steven G. Pratt, M.D. and Kathy Matthews
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 Check with your health care provider if you are on oral medications to see if grapefruit juice will interfere.
While whole fruits are the best choice, there are times when you're shopping for another form of citrus—something to spread on your toast. Citrus marmalade can be good for you: the flavonoids found in citrus fruit, which help strengthen capillaries and enhance the effects of vitamin C, survive the manufacturing process when being made into marmalade, as do many of the antioxidants and liminoids. |
Phyllis A. Balch, CNC
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| Drink a glass of grapefruit juice or Lemon Quality Water with 2 tablespoons of pure cold-processed olive oil added. This aids in cleansing and healing the gallbladder.
Lunch and Dinner
Shred 1 beet, 1 carrot, 1 turnip, V4 head of cabbage, and V* onion, all raw. Toss with a dressing made from 1 cup virgin olive oil; the juice of one lemon; V4 teaspoon of barley malt, rice malt sweetener, or blackstrap molasses; a pinch of dried parsley; and a dash of garlic powder or fresh garlic juice.
Take 1 tablespoon of a fiber supplement such as oat bran, glucomannan, or psyllium seed. |
Schuyler W. Lininger, Jr. DC
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 Whether grapefruit juice actually causes kidney stone recurrence or is merely associated with something else that increases risks remains unclear; some nutritionally oriented doctors suggest that people with a history of stones should restrict grapefruit juice intake until more is known.
Bran, a rich source of insoluble fiber (p. 293), reduces the absorption of calcium, which in turn causes urinary calcium to fall.28 In one trial, risk of forming kidney stones was significantly reduced simply by adding one-half ounce of rice bran per day to the diet. |
Phyllis A. Balch, CNC
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| Before Retiring
Drink another glass of grapefruit juice or Lemon Quality Water with 2 tablespoons of pure cold-processed olive oil added.
Use a cleansing enema, if you are constipated or having symptoms of toxicity such as lethargy or headaches. This is especially helpful if this is your first fast. If you prefer, you can use an herbal laxative such as Naturalax 2 from Nature's Way. These work well when used occasionally.
Decision Point 1
At this point, you can continue with the six-day plan or repeat Day 3 on Days 4, 5, and 6 before going on. |
H. Winter Griffith, M.D.
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| Beverages:
Caffeine drinks.
grapefruit juice.
Causes rapid heartbeat. Use with care. Toxicity risk. Avoid.
Cocaine:
Irregular heartbeat. Avoid.
Foods:
None expected.
Marijuana:
Can cause fainting.
Tobacco:
Irregular heartbeat. Avoid.
BRAND NAMES
Legatrin NovoQuinine Quin-260 Quin-amino
Quinamm Quindan Quiphile Q-Vel
BASIC INFORMATION
Habit forming? No Prescription needed? Yes Available as generic? Yes Drug class: Antiprotozoal
Treatment or prevention of malaria. • Relief of muscle cramps. |
James A. Duke, Ph.D.
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 WHAT YOU NEED
16 ounces pineapple juice
4 ounces grapefruit juice
4 ounces celery juice
1-2 teaspoons turmeric
1-2 teaspoons grated fresh ginger
1-2 cardamom fruits
Ground black and/or red (cayenne) pepper
Licorice stick (optional)
WHAT TO DO
In a blender, mix the pineapple juice and grapefruit juice. Add the celery juice. Blend in the turmeric, ginger, and cardamom. Add the pepper to taste. Stir with a licorice stick (if using).
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