Jonny Bowden, Ph.D., C.N.S.
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 Other citrus juices do not have this effect; grapefruit juice has the opposite effect and should be avoided if you're prone to kidney stones.)
Lemon Peel and Hot Black Tea for Reduced Risk of Skin Cancer
Most of us know that lemons, like other citrus fruits, are a great source of vitamin C, a powerful antioxidant as well as an anti-inflammatory agent. For that reason alone, lemons would be a healthy fruit. |
Elaine Magee
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 Orange juice contains around 124 milligrams of vitamin C and 484 milligrams of potassium per cup, and grapefruit juice contains around 94 milligrams of vitamin C and ttiwr Fnnn qvmpdrv i m t n a p t i n m
388 milligrams of potassium. Speaking of grapefruit, red grapefruit has been shown to have antioxidant synergy, and it's also rich in the high antioxidant lycopene.
Citrus fruits are suspected of some synergy with soy because vitamin C and phytoestrogens may help inhibit LDL cholesterol oxidation. |
the Editors of FC&A Medical Publishing
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 A word of caution
If you love grapefruit juice, you have two things to watch out for drug interactions and kidney stones.
Grapefruit juice can affect the way your body handles certain drugs. Sometimes it blocks absorption, and other times it makes your body absorb the drug faster. Always check with your doctor or pharmacist before taking any medication with grapefruit juice.
If you're prone to kidney stones, research shows you can lower your risk by drinking more fluids. But don't choose grapefruit juice. |
by Michael Murray, N.D. and Joseph Pizzorno, N.D.
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| Instead of your morning glass of OJ, have a glass of grapefruit juice.
Grapefruit sections add a tangy spark to green salads.
Sprinkle grapefruit halves with maple syrup, cinnamon, and nutmeg, and grill.
Combine diced grapefruit with cilantro and chili peppers to make a unique salsa.
Freeze grapefruit juice in ice cube trays and then puree in a food processor to make a simple and refreshing granita.
For a salad with a tropical flair, combine chopped grapefruit pieces, cooked shrimp, and chopped avocado and serve on a bed of romaine lettuce. |
Phyllis A. Balch, CNC
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 Do not drink grapefruit juice along with blood pressure medications or cyclosporine (a transplant drug); doing this may increase the effect of these drugs. It was discovered in 1991 that grapefruit juice has the ability to inhibit an enzyme that metabolizes many drugs, thus allowing levels of the drugs to build up in the body. Older adults may have a special susceptibility to this reaction.
The U.S. |
Schuyler W. Lininger, Jr. DC
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 Drinking grapefruit juice has actually been linked to an increased risk of kidney stones in two large studies.26,27 Whether grapefruit juice actually causes kidney stone recurrence or is merely associated with something else that increases risks remains unclear; some nutritionally oriented doctors suggest that people with a history of stones should restrict grapefruit juice intake until more is known.
Bran, a rich source of insoluble fiber (p. 293), reduces the absorption of calcium, which in turn causes urinary calcium to fall. |
Joe Graedon, M.S. and Teresa Graedon, Ph.D.
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 One popular grapefruit diet has people either eating half a grapefruit or drinking 8 ounces of grapefruit juice three or four times daily. We haven't seen any studies showing that eating grapefruit will actually make anyone thinner, but new research does demonstrate that grapefruit can help lower cholesterol.
Scientists divided 57 volunteers into three groups of 19 people each. All of the subjects had undergone coronary bypass surgery, and all had high cholesterol and triglycerides. One group got a red grapefruit each day for a month; a second group got a white grapefruit daily. |
| Despite our great excitement about pomegranate juice, we do wish to offer a word of caution: Pomegranate juice appears to interfere with certain medications much as grapefruit juice does.499 At the time of this writing, this interaction has been demonstrated only in animals, so we don't know whether it poses a serious problem for humans. Until we know for sure, ask your physician and pharmacist to review your medications to see if there could be an interaction issue.
Grapefruit
Grapefruit has long had a reputation as a health food. |
| Downside: Some preliminary evidence suggests that pomegranate juice might interact with some prescription drugs (including statins) in a manner similar to grapefruit juice. That could make these medications more likely to cause side effects. Too much juice may be constipating. Cost: Pure pomegranate juice is pricey. A month's worth could run into hundreds of dollars unless you purchase pomegranate juice concentrate. Check out www.healingfruits.com for affordable products. A 1- to 2-month supply costs around $25. an initial step in the development of atherosclerosis. |
Frederic Vagnini, M.D. and Barry Fox, Ph.D.
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 You can also eat foods that contain the depleted nutrients:
Biotin: beef liver, soybeans, rice bran, peanut butter, barley
Inositol: cantaloupe, oranges, green beans, grapefruit juice, limes
Thiamin: braised liver, turkey heart, roasted chicken, gefilte fish, sardines
Calcium: milk, dried figs, Swiss cheese, yogurt, tofu
Consult with your physician before making any changes to your diet or supplemental regimen. |
The Editors of FC&A
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| Orange juice has five times less citric acid than its popular counterpart. And grapefruit juice, despite its citric acid, may increase your odds of forming kidney stones.
Snack:
low-fat yogurt
dried fruit trail mix
Calcium from foods like yogurt may bind with the oxalate in your system and make it harmless. Besides yogurt, the mineral's sources include other low-fat dairy products, sardines, broccoli, black-eyed peas, and turnip greens.
You can tell kidney stones to take a hike with the magnesium you'll get from the dried fruit trail mix. |
Phyllis A. Balch, CNC
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| In short, it has been found that grapefruit juice increases the bioavailability of many drugs (makes their concentration higher in the body) by inhibiting the CYP3A4 enzyme in the small intestine. Some drugs that appear to be affected are:
The antihypertensive drugs felodipine (Plendil), nifedipine (Adalat, Procardia), and nitrendipine (Concept, Nitrepin).
The cholesterol-lowering drugs lovastatin (Advicor) and simvastatin (Zocor).
The sedatives (benzodiazepine types) alprazolam (Xanax), diazepam (Valium), midazolam (Versed), and triazolam (Halcion). |
by Michael Murray, N.D. and Joseph Pizzorno, N.D.
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| Anthocyanin flavonoids are found in I
WARNING: If you are taking a prescription medication for lowering cholesterol, ask your doctor if you should avoid eating grapefruit or drinking grapefruit juice. Grapefruit reduces the activity enzymes in the liver that your body uses to break down cholesterol-lowering "statin" drugs. If the drugs are not metabolized, they remain in the body in higher concentrations. This increases the risk of unwanted toxic effects, such as liver or muscle damage. |
David Heber, M.D., Ph.D.
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 When taken at usual doses, the blood levels of the drug are found to be twice as high after drinking double-strength grapefruit juice for three days. There is an enzyme on the surface of the small intestine whose production is inhibited by chemicals in the grapefruit juice. This type of interaction of chemicals in grapefruit juice with your genes is an example of how diet can powerfully affect the body's enzyme systems. There are many other examples mentioned later, but the point is that these enzyme changes also can protect your body from chemicals in the diet or the environment. |
The Life Extension Editorial Staff
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 L/kg daily of purple grape juice, grapefruit juice, or orange juice for 1 week. Drinking purple grape juice reduced platelet aggregation by 77%. Orange and grapefruit juice had no effect. The authors proposed that the flavonoids in grape juice may decrease the risk of thrombosis (Keevil et al. 2000).
Sulfur-Containing Compounds N-Acetyl-L-Cysteine
The amino acid N-acetyl-L-cysteine (NAC) inhibits platelet aggregation by several mechanisms, including:
Increasing the antiplatelet aggregrating effects of L-arginine, which promotes endogenous synthesis of nitric oxide (Anfossi et al. |
Paula Begoun
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 Beyond this issue is the fact that Nexxus added an appreciable amount of grapefruit juice to this conditioner, which can be very irritating to the scalp and drying to hair.
© Headress Volumizing Leave-In Conditioner ($18 for 13.5 ounces) could have been an excellent leave-in conditioner for all hair types, but it contains the preservatives methylchloroisothiazolinone and methylisothiazolinone (Kathon CG), which are not recommended for use in leave-in products due to their risk of causing a sensitizing reaction on the scalp.
© $$$ Humectress Ultimate Moisturizing Conditioner ($16for 13. |
by Michael Murray, N.D. and Joseph Pizzorno, N.D.
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| If you are taking a prescription medication, ask your doctor if you should avoid eating grapefruit or drinking grapefruit juice.
Some drugs, such as Neoral (oral cyclosporine), already carry a warning. For a complete list of drugs currently known to be affected by grapefruit, see www.drug-interactions.com.
Fortunately for citrus lovers, oranges and tangerines do not contain significant amounts of naringin but have many other important nutrients and flavonoids.
Grapes
Grapes are well-known small round or oval berries that feature a semitranslucent flesh encased by a smooth skin. |
Sheldon Saul Hendler and David Rorvik
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 FOODS
Grapefruit juice: grapefruit juice contains some substances, such as the furanocoumarin bergamottin, which inhibit cytochrome P450 3A4, the enzyme that metabolizes lovastatin, among other substances. Therefore, concomitant use of red yeast rice and grapefruit juice may increase the risk of myopathy.
Meals: When lovastatin was given under fasting conditions, plasma concentrations of lovastatin and its active metabolite were on the average two-thirds those found when lovastatin was administered immediately following a meal. |
Mary-Ann Shearer
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 Even taking in honey or grapefruit juice does not make it a true fast.
During a fast, the body redirects the energy it would otherwise use for digesting meals and other daily activities to any problem area in the body. In other words, the body is given an opportunity to focus on cleansing and healing. Weight loss is also achieved more quickly on a fast as the body burns any excess fat deposits for fueling its normal functions. (The average weight loss is from 1-2 pounds per day.)
A word of caution is needed here. |
Frederic Vagnini, M.D. and Barry Fox, Ph.D.
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| You can also eat foods that contain the depleted nutrient:
Inositol: cantaloupe, oranges, green beans, grapefruit juice, limes
Consult with your physician before making any changes to your diet or supplemental regimen.
LOMEFLOXACIN (loe-me-FLOKS-uh-sin) Brand Name: Maxaquin
About Lomefloxacin
The kidneys, which are placed to the right and left of the spine in the lower-middle portion of the back, continually filter waste products out of the blood and mix them with water to produce urine. |
Joseph E. Mario
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 Gallbladder Stone Flushes: If not removed by dietary changes, fast for 2 days, taking Apple juice every 2 hours; then do the fol lowing oil flush: Take half to 3/4 pint of unrefined Olive, Walnut, Sunflower, or Poppy seed oil (with Lemon or grapefruit juice) forcopious Bile secretion to flush small to medium stones; lie down and remain on your right side for about two hours, or go to bed; and drink something hot in the morning.
Or Take 8 oz. fresh Citrusjuice including 1 Lemon, blended with 8 oz. of Olive oil; and drink 4 oz. every hour for 4 hours (starting at 6 p.m. |
Jonny Bowden, Ph.D., C.N.S.
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| Overall, only the fresh grapefruit group reached "statistical significance," but among those with metabolic syndrome, all three grapefruit groups lost significantly more weight. Insulin resistance was improved in everyone. The authors admitted that the mechanism isn't understood, but that it would be prudent to include fresh grapefruit in a weight loss diet.
Why Smokers Should Eat More Grapefruit
Meanwhile, even if you're not trying to lose weight, grapefruit's still a good food. |
Jack Challem
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 In contrast, subjects taking the placebos lost only one-half pound. One-third of the subjects were prediabetic, and those who consumed the fresh juice or the grapefruit benefited from significant reductions in fasting and postmeal insulin levels.
Why would grapefruit have these effects, despite the calories it adds? First, as we discussed in chapter 3, not all calories are equal. Second, grapefruit contains compounds that are known to reduce the activity of the liver enzymes involved in breaking down drugs. |
Alan Keith Tillotson, Ph.D., A.H.G., D.Ay.
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 This may explain why grapefruit juice increases the effects of many prescription drugs. When certain drugs are ingested with grapefruit juice, the blood levels of those drugs can reach five times their normal levels, which is especially dangerous with cardiac glycosides.
These concerns are limited to people taking drugs where lowering below therapeutic levels is dangerous. If you are not taking such medicines you certainly can drink grapefruit juice.
Blood Thinners
Many herbs contain mild to moderate blood-thinning or -thickening properties. |
Patricia Hausman & Judith Benn Hurley
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 Use some grapefruit juice to vary the flavor of punches and dressings for fruit salads.
% pound sea scallops 2 pink grapefruits, sectioned
1 tablespoon minced fresh chives
2 tablespoons grapefruit juice
1 tablespoon hazelnut oil Yz teaspoon Dijon mustard red lettuce leaves
Scallop and Pink Grapefruit Salad
Cut larger scallops in half, then steam scallops in boiling water, covered, until cooked through, about 2 to 3 minutes.
In a large bowl, combine grapefruit sections and chives. Add scallops.
In a small bowl, whisk together grapefruit juice, oil, and mustard. |
James F. Balch, M.D. and Mark Stengler, N.D.
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 Avoid grapefruit juice, which studies show increases the risk of kidney stones.
Animal fat causes the body to excrete calcium, creating a build-up in the kidneys. Avoid all red meat, and limit your consumption of other animal products.
Avoid calcium overload by eliminating dairy products from your diet. The calcium from milk, cheese, ice cream, and the like is not easily absorbed by the digestive system and ends up as extra waste matter in your kidneys.
When you eat too much sugar, the resulting high levels of insulin leach calcium from the bones and divert it into the urinary tract. |
Textbook of Natural Medicine 2nd Edition Volume 1Michael T. Murray, ND
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| This flavonoid is found in grapefruit juice, but not in orange juice. Studies in humans have shown grapefruit juice (i.e. naringin) to increase the oral bioavailability of drugs like nifedipine, felodipine, verapramil, and terfenadine, as well as inhibiting the breakdown of various drugs, particularly caffeine, coumarin, and estrogens.48 Avoidance of grapefruit juice and flavonoid preparations containing naringin is recommended when taking any of these drugs.
REFERENCES
1. Hertog MG, Feskens EJ, Hollman PC et al. |
Patricia Hausman & Judith Benn Hurley
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| Mix grapefruit juice half-and-half with club soda and garnish with a twist of lime.
Use some grapefruit juice to vary the flavor of punches and dressings for fruit salads.
% pound sea scallops 2 pink grapefruits, sectioned
1 tablespoon minced fresh chives
2 tablespoons grapefruit juice
1 tablespoon hazelnut oil Yz teaspoon Dijon mustard red lettuce leaves
Scallop and Pink Grapefruit Salad
Cut larger scallops in half, then steam scallops in boiling water, covered, until cooked through, about 2 to 3 minutes.
In a large bowl, combine grapefruit sections and chives. Add scallops. |
Joseph E. Mario
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| Taken with grapefruit juice to neutralize the bitterness; provides 6 hours of enhanced audio/visual perceptions. Synthetically adding a methyl group to the side-chain of mescaline yields 3,4,5-TriMethoxyAmphetamine (TMA) with greater potency by retaining of the Nitrogen side-chain. Other metabolites of 2,5-DiemthyOxy-4-Methylamphetamine (DOM/STP); 2,5-DimethOxy-4-Ethylamphetamine (DOET) that increases self-awareness and euphoria; as does 3,4-MethyleneDioxy-n-MethylAmphetamine (MDMA/Ecstacy drug). Pipizintzintli SEE Hojas de la Pastora above. |
Patricia Hausman & Judith Benn Hurley
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| Grapefruit Juice
At the Market: Supermarkets sell grapefruit juice in canned and frozen forms, but specialty shops and juice bars are more likely to have freshly made juice. If you have a juicer, consider making your own-it takes a lot less time than you might think, and the fresher flavor is worth the effort.
Kitchen Tips: Store juice in a clean glass jar or bottle in the refrigerator. Reconstituted frozen and canned grapefruit juice will last for about a week in the refrigerator. Fresh juice is more perishable and should be used within two days. |
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